Chlorella is a unicellular plant of the chlorella family of green algae and is known that Chlorella is rich in Vitamin K. Therefore, mechanism of warfarin antagonistic action of Chlorella may be due to the direct action of Vitamin K. Until now, studies have not been conducted for the effect of food containing large amounts of vitamin K on TT value. Karlson et. al.6) studied the effect of TT value when 250g of green leafy vegetables spinach and broccoli were respectively consumed only once and when consumed continuously for one week and reported that there is no effect when consumed only once while TT value increased significantly when consumed continuously for one week. In this case, Vitamin K1 in 250g of spinach and broccoli were 300 to 800µg and 160 to 500µg respectively. The food analysis of the chlorella ingested by this patient could not be carried out. The report by Suta mentions that 100g of Chlorella contains 3.6mg of Vitamin K1 (Japan Association of Inspection and Investigation Including Foods Fats and Oils, July 19, 1990).
Vitamin K1 in 6g of Chlorella is 216 µg when calculated using this value and this corresponds to the vitamin K1 content in 250g of Broccoli. In this case, when consumed continuously for more than one week, changes in TT value can be observed, but the effect when consumed only once is not known.